Clinical vignettes are essential educational tools in speech-language pathology (SLP), but manual creation is time-intensive. While general-purpose large language models (LLMs) can generate text, they lack domain-specific knowledge, leading to hallucinations and requiring extensive expert revision. This study presents a proof-of-concept system integrating retrieval-augmented generation (RAG) with curated knowledge bases to generate pediatric SLP case materials. A multi-model RAG-based system was prototyped integrating curated domain knowledge with engineered prompt templates, supporting five commercial (GPT-4o, Claude 3.5 Sonnet, Gemini 2.5 Pro) and open-source (Llama 3.2, Qwen 2.5-7B) LLMs. Seven test scenarios spanning diverse disorder types and grade levels were systematically designed. Generated cases underwent automated quality assessment using a multi-dimensional rubric evaluating structural completeness, internal consistency, clinical appropriateness, and IEP goal/session note quality. This proof-of-concept demonstrates technical feasibility for RAG-augmented generation of pediatric SLP vignettes. Commercial models showed marginal quality advantages, but open-source alternatives achieved acceptable performance, suggesting potential for privacy-preserving institutional deployment. Integration of curated knowledge bases enabled content generation aligned with professional guidelines. Extensive validation through expert review, student pilot testing, and psychometric evaluation is required before educational or research implementation. Future applications may extend to clinical decision support, automated IEP goal generation, and clinical reflection training.

Electrocardiogram (ECG) interpretation is essential for cardiovascular disease diagnosis, but current automated systems often struggle with transparency and generalization to unseen conditions. To address this, we introduce ZETA, a zero-shot multimodal framework designed for interpretable ECG diagnosis aligned with clinical workflows. ZETA uniquely compares ECG signals against structured positive and negative clinical observations, which are curated through an LLM-assisted, expert-validated process, thereby mimicking differential diagnosis. Our approach leverages a pre-trained multimodal model to align ECG and text embeddings without disease-specific fine-tuning. Empirical evaluations demonstrate ZETA's competitive zero-shot classification performance and, importantly, provide qualitative and quantitative evidence of enhanced interpretability, grounding predictions in specific, clinically relevant positive and negative diagnostic features. ZETA underscores the potential of aligning ECG analysis with structured clinical knowledge for building more transparent, generalizable, and trustworthy AI diagnostic systems. We will release the curated observation dataset and code to facilitate future research.

Modeling disease progression through multiple stages is critical for clinical decision-making for chronic diseases, e.g., cancer, diabetes, chronic kidney diseases, and so on. Existing approaches often model the disease progression as a uniform trajectory pattern at the population level. However, chronic diseases are highly heterogeneous and often have multiple progression patterns depending on a patient's individual genetics and environmental effects due to lifestyles. We propose a personalized disease progression model to jointly learn the heterogeneous progression patterns and groups of genetic profiles. In particular, an end-to-end pipeline is designed to simultaneously infer the characteristics of patients from genetic markers using a variational autoencoder and how it drives the disease progressions using an RNN-based state-space model based on clinical observations. Our proposed model shows improvement on real-world and synthetic clinical data.